C Elegans Vulval Dev
The anchor cell is a cell in nematodes such as Caenorhabditis elegans. It is important in the development of the reproductive system, as it is required for the production of the tube of cells that allows embryos to pass from the uterus through the vulva to the outside of the worm.
Jun 01, 2015 A little over 50 years ago, Sydney Brenner had the foresight to develop the nematode (round worm) Caenorhabditis elegans as a genetic model for understanding questions of developmental biology and neurobiology. Over time, research on C. Elegans has expanded to explore a wealth of diverse areas in modern biology including studies of the basic functions and interactions of eukaryotic cells.
During the development of C. eleganshermaphrodites, the anchor cell produces a signalling molecule (LIN-3/EGF) that induces nearby epidermal cells to develop into the vulva.[1] The anchor cell also produces another signal (the Notch ligand LAG-2) that induces adjacent uterine cells to become the π cells,[2] some of which will later connect the uterus to the vulva.[3] The anchor cell next removes the basement membrane that separates the uterus and vulva and invades, initiating the connection between the uterus and the vulva.[4] Finally the anchor cell fuses with eight of the π cells to form the uterine seam cell.[3]
References[edit]
C Elegans Vulval Dev 2
- ^Hill RJ, Sternberg PW (August 1992). 'The gene lin-3 encodes an inductive signal for vulval development in C. elegans'. Nature. 358 (6386): 470–6. doi:10.1038/358470a0. PMID1641037.
- ^Newman AP, White JG, Sternberg PW (February 1995). 'The Caenorhabditis elegans lin-12 gene mediates induction of ventral uterine specialization by the anchor cell'. Development. 121 (2): 263–71. PMID7768171.
- ^ abNewman AP, White JG, Sternberg PW (November 1996). 'Morphogenesis of the C. elegans hermaphrodite uterus'. Development. 122 (11): 3617–26. PMID8951077.
- ^Sherwood DR, Sternberg PW (July 2003). 'Anchor cell invasion into the vulval epithelium in C. elegans'. Dev. Cell. 5 (1): 21–31. doi:10.1016/S1534-5807(03)00168-0. PMID12852849.
External links[edit]
C Elegans Vulval Dev Test
- Anchor cell page at Wormbase – part of the anatomy ontology of C. elegans.